General Strategy for Direct Cytosolic Protein Delivery via Protein–Nanoparticle Co-engineering
نویسندگان
چکیده
منابع مشابه
Biomimetic nanocarrier for direct cytosolic drug delivery.
The ability to transport a large quantity of drug molecules into cytosolic compartments of cancer cells has powerful implications in modern molecular therapeutics because the sites of action of the drugs are often cytosolic organelles. Furthermore, direct cytosolic delivery might offer a means to evade efflux transporters, such as multidrug-resistance proteins and P-glycoproteins. Nanoparticle ...
متن کاملHydrogels for protein delivery in tissue engineering.
Tissue defects caused by diseases or trauma present enormous challenges in regenerative medicine. Recently, a better understanding of the biological processes underlying tissue repair led to the establishment of new approaches in tissue engineering which comprise the combination of biodegradable scaffolds and appropriate cells together with specific environmental cues, such as growth or adhesiv...
متن کاملExpressed protein ligation: a general method for protein engineering.
A protein semisynthesis method-expressed protein ligation-is described that involves the chemoselective addition of a peptide to a recombinant protein. This method was used to ligate a phosphotyrosine peptide to the C terminus of the protein tyrosine kinase C-terminal Src kinase (Csk). By intercepting a thioester generated in the recombinant protein with an N-terminal cysteine containing synthe...
متن کاملDirect Delivery of Antigens to Dendritic Cells via Antibodies Specific for Endocytic Receptors as a Promising Strategy for Future Therapies
Dendritic cells (DCs) are the most potent professional antigen presenting cells and are therefore indispensable for the control of immunity. The technique of antibody mediated antigen targeting to DC subsets has been the basis of intense research for more than a decade. Many murine studies have utilized this approach of antigen delivery to various kinds of endocytic receptors of DCs both in vit...
متن کاملA general strategy for organocatalytic activation of C-H bonds via photoredox catalysis: direct arylation of benzylic ethers.
Direct C-H functionalization and arylation of benzyl ethers has been accomplished via photoredox organocatalysis. The productive merger of a thiol catalyst and a commercially available iridium photoredox catalyst in the presence of household light directly affords benzylic arylation products in good to excellent yield. The utility of this methodology is further demonstrated in direct arylation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Nano
سال: 2017
ISSN: 1936-0851,1936-086X
DOI: 10.1021/acsnano.7b02884